Pharmaceutical Intermediate
How does Paxlovid work? Dec 03 , 2021

How does Paxlovid work?

Paxlovid is a combination of Pfizer’s investigational antiviral PF-07321332 and a low dose of ritonavir, an antiretroviral medication traditionally used to treat HIV. The treatment disrupts the replication of SARS-CoV-2 in the body by binding to the 3CL-like protease, an enzyme crucial to the virus’ function and reproduction.

According to an interim analysis, Paxlovid reduced the risk of Covid-19-associated hospitalisation or death by 89% in those who received treatment within three days of symptom onset. The drug was found to be so effective – just 1% of patients who received Paxlovid were hospitalised through day 28 compared to 6.7% of placebo participants – that its Phase II/III trial was ended early and regulatory submission to the FDA was filed sooner than expected. Moreover, while 10 deaths were reported on the placebo arm, none occurred among participants who received Paxlovid.

Like molnupiravir, Paxlovid is administered orally, meaning Covid-19 patients can take the drug at home in the early stages of infection. The hope is that new antivirals like those from Merck and Pfizer will allow people with mild or moderate cases of coronavirus to be treated sooner, preventing disease progression and help avoid hospitals from being overwhelmed.

Leave A Message
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.

Home

Products

skype

whatsapp